Calvin Mehl
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Norway rats (Rattus norvegicus) are synanthropic rodents associated with a wide variety of pathogens. In Iran, limited information exists on the prevalence and diversity of zoonotic pathogens in commensal rodents. In this study, approximately 100 wild Norway rats from the capital Tehran were screened by RT-PCR and PCR assays for the presence of various bacterial and viral agents.
Five viral and three bacterial agents were detected, including four zoonotic agents. The most prevalent RNA viruses were murine kobuvirus-1 (MuKV1), rat astrovirus (RAstV), and rat hepatitis E virus, with several animals being coinfected with these viruses. Leptospira interrogans DNA was found in about 6% of rats, while Bartonella spp. DNA was found in 14% of rats. Streptobacillus moniliformis DNA was detected in 14.3% of faecal samples. Rattus norvegicus polyomavirus 1 (RnorPyV1) DNA was detected at very low prevalence.
The high prevalence of some zoonotic and animal pathogens may have implications for local communities. Genome characterization of these pathogens provide a better understanding of their genomic diversity in this region and may improve diagnostic capabilities. A future One Health approach, integrating pathogens in humans, animals, and the environment, would allow for a greater understanding of rat-borne zoonotic infection risk in this city.
Keywords
Rattus norvegicus, pathogens, viruses, zoonoses
| Registration ID |
OHS25-0063
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| Professional Status of the Speaker |
Postdoc
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| Junior Scientist Status |
No, I am not a Junior Scientist.
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Calvin Mehl
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Mohammad Reza Abai
(Tehran University of Medical Sciences, School of Public Health, Department of Medical Entomology and Vector Control)
Patricia König
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Donata Hoffmann
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Gereon Schares
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Emilija Vasiliūnaitė
(Institute of Biotechnology, Life Sciences Center, Vilnius University)
Katja Schilling-Loeffler
(German Federal Institute for Risk Assessment)
Sonja Jacobsen
(Robert Koch-Institute, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases)
Sindy Böttcher
(Robert Koch-Institute, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases)
Alma Gedvilaitė
(Institute of Biotechnology, Life Sciences Center, Vilnius University)
Tobias Eisenberg
(Hessian State Laboratory, Department Veterinary Medicine)
Herbert Tomaso
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
Anna Obiegala
(University of Leipzig, Institute of Animal Hygiene and Veterinary Public Health)
Reimar Johne
(German Federal Institute for Risk Assessment)
Martin Pfeffer
(University of Leipzig, Institute of Animal Hygiene and Veterinary Public Health)
Sandra Niendorf
(Robert Koch-Institute, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases)
Gerald Heckel
(Institute of Ecology and Evolution, University of Bern)
Rainer G. Ulrich
(Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health)
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