Lea Lenhard
(Institute of Diagnostic Virology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany; Bavarian Health and Food Safety Authority, Munich, Germany; Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany)
Borna disease virus 1 (BoDV-1) causes mostly fatal encephalitis in humans and other mammals. Its distribution area is restricted to parts of Southern and Eastern Germany, Austria, Switzerland and Liechtenstein. Spillover to dead-end hosts results from direct and/or indirect contact to bicolored white-toothed shrews (Crocidura leucodon), the natural BoDV-1 reservoir, which shed the virus via urine, feces, saliva and skin, but remain unaffected by the disease.
As part of this project, 263 shrews, predominately from Bavaria, were tested for BoDV-1 and their species was determined by a newly established RT-qPCR assay targeting the cytochrome b gene. Twenty-four (26.4%) of 91 C. leucodon as well as one out of 11 (9.1%) Mediterranean water shrews (Neomys anomalus) tested positive for BoDV-1, all of which originated from Bavaria. Phylogenetic analyses demonstrated the BoDV-1 sequences to belong to the same local clusters as found in Borna disease cases in the respective regions.
Several BoDV-1-positive shrews were found in human dwellings. Environmental samples were collected in five instances two to four weeks later, revealing low levels of BoDV-1 RNA but no infectious virus. In two cases, submitters had experienced close contact to excretions of BoDV-1-positive shrews, initiating post-exposure prophylaxis and 12-months of monitoring.
This One Health approach refines BoDV-1 risk areas and provides valuable insights into the poorly defined human-animal interface of BoDV-1 infection.
Keywords
BoDV-1, public health management, screening,
| Registration ID |
OHS25-141
|
| Professional Status of the Speaker |
Postdoc
|
| Junior Scientist Status |
Yes, I am a Junior Scientist.
|
Lea Lenhard
(Institute of Diagnostic Virology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany; Bavarian Health and Food Safety Authority, Munich, Germany; Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany)
Philipp Starcky
(Institute of Diagnostic Virology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany; Bavarian Health and Food Safety Authority, Munich, Germany; Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany)
Prof.
Barbara Schmidt
(Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany, Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany; Institute of Medical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany)
Kinga Szathmari
(Bavarian Health and Food Safety Authority, Munich, Germany)
Dr
Markus Bauswein
(Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany)
Dr
Viola C. Haring
(Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany)
Prof.
Rainer G. Ulrich
(Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany)
Prof.
Martin Beer
(Institute of Diagnostic Virology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany)
Dr
Merle M. Böhmer
(Bavarian Health and Food Safety Authority, Munich, Germany; Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany; Institute of Social Medicine and Health Systems Research, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany)
Dr
Dennis Rubbenstroth
(Institute of Diagnostic Virology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany; Zoonotic Bornavirus-Focal Point Bavaria (ZooBoFo) 2.0, Germany)
There are no materials yet.
