Conveners
Session 1: AMR
- Roswitha Merle
- Birgit Walther
Non-heritable phenotypic drug resistance toward antibiotics challenges antibiotic therapies, and phenotypic resistance fosters the evolution of heritable resistance. Here, we describe single-cell characteristics of phenotypic resistant E. coli cells and compare those to characteristics of susceptible cells by exposure to different levels of recurrent ampicillin antibiotic. Contrasting...
The selective pressure exerted by the massive use of antibiotics has led to a rise in antimicrobial resistance (AMR), posing a serious global health problem. This issue is particularly concerning in many regions of Sub-Saharan Africa, where easy access to antibiotics without a prescription and frequent self-medication foster the emergence and spread of antibiotic resistance genes (ARGs). This...
Antimicrobial resistance poses a significant challenge to global health. However, the factors that maintain antimicrobial resistance genes (ARGs) within wildlife microbiomes, particularly in species inhabiting human-dominated landscapes, remain unclear. In this study, we analysed ARGs in 846 faecal samples collected from house mice (Mus musculus) on farms in Germany between 2016 and 2022...
Staphylococcal species are well-known zoonotic opportunistic pathogens leading to clinical symptoms that range from skin and soft tissue infections to severe blood stream infections as well as human food poisoning. In 2015, S. argenteus was defined as a separate species within the S. aureus complex but with a similar pathogenicity in humans, proven by occasional infectious disease and...
Background: Inappropriate use of antimicrobials has been linked to resistance to antibiotics in both humans and animals. About three quarters of total antimicrobial use (AMU) originates in agriculture, but a comprehensive understanding of options for reducing agricultural AMU is lacking. Here we estimate the effectiveness of mitigation options across the food system at global, regional, and...
Antimicrobial resistance is a global health concern caused by the overuse of antimicrobials and environmental contamination. Wildlife exposed to disturbed environments can acquire resistant microorganisms, indicating environmental ARG (antimicrobial resistance genes) contamination and serving as ARG reservoirs. Here, we used a landscape-scale approach to test whether metrics of anthropogenic...
SARS-CoV-2 infections can have severe consequences, especially for elderly and immunosuppressed individuals. Identifying novel antiviral treatment strategies is an important task, especially in preventing the selection of resistant virus variants. Such treatment strategies include host targeting antivirals (HTAs) and direct acting antivirals (DAAs), each with distinct benefits. Here, we show...
