Conveners
Session 7: Virus Replication and Innate Immunity
- Klaus Schughart
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Aartjan te Velthuis9/15/26, 1:30 PMOral presentation
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Nicole Oberberg9/15/26, 2:00 PMVirus ReplicationOral presentation
Influenza A viruses (IAV) activate MAPK/ERK in a biphasic manner to promote viral replication. The family of 90 kDa ribosomal S6 kinases (RSK) belongs to the downstream effectors of MAPK/ERK and is involved in cell growth, proliferation and differentiation. We have previously shown, that the RSK1 isoform mediates the nuclear release of newly produced vRNPs via direct phosphorylation of the...
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Margot SARRAT (INRAE ENVT)9/15/26, 2:20 PMVirus ReplicationOral presentation
In 1998, an H3N2 swine influenza virus emerged following reassortment between avian, human, and swine viruses, acquiring avian-derived PB2 and PA segments. PB2 subsequently adapted to pigs through the acquisition of the triple mutation 271A, 590S, and 591R. Although the key role of the viral polymerase complex in the adaptation of avian influenza A viruses to mammals is well established, and...
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Samuel Kindylides (Sciensano)9/15/26, 2:40 PMInnate immunityOral presentation
Since 2021, clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses (HPAIVs) have become predominant worldwide, displaying increased virulence and dissemination in poultry and waterfowl. Within the framework of the WiLiMan-ID project, our goal is to gain insight into the mechanisms shaping host-pathogen interactions and contributing to the enhanced virulence of recent HPAIVs. To this...
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