Disease outbreaks and management are a huge challenge for public health systems worldwide. The excessive use of drugs in veterinary and human medicine leads to a reduction in effectiveness and even to the development of antimicrobial resistances(AMR). Monitoring AMR as well as the coinfection with neglected tropical diseases (NTDs) remains a significant challenge especially across sub-Saharan...
Introduction
Heteroresistance (HR) describes the ability of a subpopulation to grow in the presence of inhibitory antibiotic concentrations. We found HR to ceftazidime (CAZ) in a clinical Enterobacter cloacae complex (ECC) strain (IMT49658).
Material & Methods
We performed extensive phenotypic (population analysis profiles, stability analysis of resistance, ScanLag) and molecular...
During the SARS-CoV-2 pandemic, several treatment strategies arose relying on viral target structures and therefore pose risks of emerging escape-mutations. We therefore screened kinase inhibitors as a strategy to modulate the host. These were selected on the basis of previously observed interference with the FGF7-singaling. These inhibitors are used in cancer therapy targeting EGFR, FGFR,...
Bacterial resistance against antibiotics has become commonplace in medical, veterinary, and environmental settings. This development is particularly driven by conjugative plasmids carrying antibiotics resistance genes, which spread easily in environments of high bacterial density. Understanding the dynamics of spread of AMR genes among commercially raised animals is a crucial component of...
In the Connect One Health Data project, routine data on resistance testing in Lower Saxony from the zoonoses monitoring (ZooMo; veterinary sector) are analysed together with data from the antibiotic resistance monitoring in Lower Saxony (ARMIN; human sector) for the years 2018-2021. Proportions of resistant isolates per antimicrobial agent in the different populations are determined.
The...
Background and objectives: Tuberculosis (TB) is the leading bacterial cause of human death worldwide. The proportion of antibiotic resistant Mycobacterium tuberculosis (Mtb) strains is increasing. The aim of this study was to analyze the effect of an orally administered anti-TB drug candidate - benzothiazinone (BTZ) - 043 on Mtb induced granulomas.
Material and Methods: Eighteen guinea...
