Dr
Silver A. Wolf
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
The Integrated Genomic Surveillance (IGS) enables monitoring of 30 prioritized pathogen groups with increased public health importance. Genomic information from notifiable cases detected throughout Germany are collected at the Robert Koch Institute (RKI). Here, sequences are integrated with case data of the German reporting system to provide a comprehensive overview on the national emergence, spread, outbreaks and evolution of pathogens, enabling the foundation for infectious disease monitoring and prevention.
Our results highlight multiple major successes of the IGS project, including establishing a centralized infrastructure for storing, analyzing and maintaining surveillance data. As part of this, the IGS Datawarehouse (IGS DWH) represents the basis for combined investigations of genomic and epidemiological data. Interacting with this are bioinformatic analyses, dashboards, interactive visualizations and automated reports. To provide these, we have developed specialized computational workflows (IGS Bioinformatics Toolkit & Omnifluss) for high-throughput genomic analyses of multi-pathogen data sets.
To date, the IGS has been used to analyze more than 1.2 million pathogen samples, including a majority of SARS-CoV-2 sequences, supporting infectious disease monitoring on a national scope. We hereby highlight the importance of establishing scalable, robust and maintainable infrastructure such as the IGS for pandemic preparedness and intersectoral One Health projects.
Keywords
Bioinformatics, Integrated Genomic Surveillance, Public Health, Pandemic Preparedness
| Registration ID |
OHS26-90
|
| Professional Status of the Speaker |
Senior Scientist
|
| Junior Scientist Status |
No, I am not a Junior Scientist.
|
Dr
Silver A. Wolf
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
André Götze
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Anne-Christine Schulz
(Integrated Genomic Surveillance Coordination (IGS), Robert Koch Institute, Berlin, Germany)
Benjamin Tittmann
(Surveillance and Electronic Reporting and Information System (FG32), Robert Koch Institute, Berlin, Germany)
Caroline Roschek
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Felix Hartkopf
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Hanna Buck
(Integrated Genomic Surveillance Coordination (IGS), Robert Koch Institute, Berlin, Germany)
Hannah Maatsch
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Katrin Kremer-Flach
(Surveillance and Electronic Reporting and Information System (FG32), Robert Koch Institute, Berlin, Germany)
Marie Lataretu
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Maximilian Driller Povill
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Nadine Litzba
(Integrated Genomic Surveillance Coordination (IGS), Robert Koch Institute, Berlin, Germany)
Paul Wolk
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Stephan Fuchs
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Torsten Houwaart
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
Torsten Semmler
(Integrated Genomic Surveillance Coordination (IGS), Robert Koch Institute, Berlin, Germany)
Yusra Seyam
(Genome Competence Centre (MF1), Robert Koch Institute, Berlin, Germany)
the IGS system development group
(Robert Koch Institute, Berlin, Germany)
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